Reply To: Depressed on Celexa Home › Forums › Introvert Health › Depressed on Celexa › Reply To: Depressed on Celexa March 26, 2022 at 5:00 pm #2810 dawnParticipant Up0Down:: Yes, Steve, I have been really well. I have experienced my first happiness for about 2 years. I am so grateful for Duloxetine and for Robby’s recommendation. You don’t know what a difference this has made. I believe Duloxetine targets major depression.